N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Base Information

Chemical Name:N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
CAS No.:1047644-97-2
Molecular Formula:C₁₉H₂₁BrN₄OS*ClH
Molecular Weight:469.833
Hs Code.:

Synonyms:N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

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Chemical Property of N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

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Technology Process of N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

There total 9 articles about N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19212-27-2
3-oxo-4-phenylbutyronitrile

: 1047644-97-2
N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C

2: tetrahydrofuran / 0.5 h

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 20 °C

4: hydrazine / tetrahydrofuran; methanol / 12 h / 50 °C

5: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 16 h / 25 °C

6: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

7: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1047643-76-4
N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide

: 1047644-97-2
N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

: 6324-10-3
4,5-Dibromo-thiophene-2-carboxylic acid

: 1047644-97-2
N-[3-amino-1-(phenylmethyl)propyl]-4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 80 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 16 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

4: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water;