2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid

Base Information

• Chemical Name: 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid
• CAS No.: 1421848-86-3
• Molecular Formula: C₁₉H₂₁N₃O₃S
• Molecular Weight: 371.46

Synonyms:2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid

Chemical Property of 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid

There total 2 articles about 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetate (1421848-85-2) → 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid (1421848-86-3)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

Reference yield:

2-bromo-1-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)ethanone (1421848-84-1) → 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid (1421848-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 14 h / 90 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C

With water; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield: 18.0%

4-tetrahydropyranmethylamine (130290-79-8) + 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid (1421848-86-3) → 2-{4-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-2-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)acetamide (1421847-26-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

upstream raw materials:

2-bromo-1-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)ethanone

ethyl 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetate

Downstream raw materials:

2-{4-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-2-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1421848-86-3 2-(4-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-2-yl)acetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send