ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate

Base Information

• Chemical Name: ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate
• CAS No.: 1449662-22-9
• Molecular Formula: C₁₃H₂₁NO₃Si
• Molecular Weight: 267.4
• Mol file: 1449662-22-9.mol

Synonyms:ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate

Chemical Property of ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate

There total 1 articles about ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-2-cyanoacrilate (7085-85-0,25067-30-5) + 2-trimethylsilyloxy-1,3-butadiene (38053-91-7) → ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate (1449662-22-9)

Guidance literature:

In 1,4-dioxane; Inert atmosphere; Sealed tube; Reflux;

Reference yield:

ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate (1449662-22-9) → ethyl 1-cyano-4-oxocyclohexanecarboxylate (58774-04-2)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

ethyl 1-cyano-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate (1449662-22-9) → ethyl 1-cyano-4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-enecarboxylate (1449662-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran / 20 °C / Inert atmosphere

2: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

With hydrogenchloride; water; potassium hexamethylsilazane; In tetrahydrofuran;

upstream raw materials:

ethyl-2-cyanoacrilate

2-trimethylsilyloxy-1,3-butadiene

Downstream raw materials:

ethyl 1-cyano-4-oxocyclohexanecarboxylate

ethyl 1-cyano-4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-enecarboxylate

ethyl 1-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate

ethyl 1-cyano-4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-enecarboxylate