Technology Process of 5-chloro-2-(chloromethyl)-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
There total 6 articles about 5-chloro-2-(chloromethyl)-3-o-tolylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
toluene;
for 40h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ammonium hydroxide; sodium hydroxide; sodium hypochlorite; Aliquat 336; ammonium chloride / diethyl ether; water; tert-butyl methyl ether / 1.83 h / 0 - 20 °C
2: acetic acid / 2 h
3: pyridinium p-toluenesulfonate / toluene / 40 h / Reflux
With
ammonium hydroxide; sodium hypochlorite; pyridinium p-toluenesulfonate; Aliquat 336; ammonium chloride; acetic acid; sodium hydroxide;
In
diethyl ether; tert-butyl methyl ether; water; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / 0.5 h / Reflux
1.2: 2 h / 60 °C
2.1: ammonium hydroxide; sodium hydroxide; sodium hypochlorite; Aliquat 336; ammonium chloride / diethyl ether; water; tert-butyl methyl ether / 1.83 h / 0 - 20 °C
3.1: acetic acid / 2 h
4.1: pyridinium p-toluenesulfonate / toluene / 40 h / Reflux
With
ammonium hydroxide; sodium hypochlorite; thionyl chloride; pyridinium p-toluenesulfonate; Aliquat 336; ammonium chloride; acetic acid; sodium hydroxide;
In
diethyl ether; tert-butyl methyl ether; water; toluene;
