N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

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Chemical Name:N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine
CAS No.:1227300-02-8
Molecular Formula:C₂₉H₂₈F₃N₇O₄S
Molecular Weight:627.647
Hs Code.:

N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

Synonyms:N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

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Chemical Property of N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

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Technology Process of N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

There total 5 articles about N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1227299-96-8
1-({6-[(3,4-Dimethoxybenzyl)(methyl)amino]pyridin-3-yl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid

: 1227298-64-7
N'-hydroxy-4-[S-(trifluoromethyl)sulphonimidoyl]benzenecarboximide amide

: 1227300-02-8
N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

Guidance literature:: 1-({6-[(3,4-Dimethoxybenzyl)(methyl)amino]pyridin-3-yl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N'-hydroxy-4-[S-(trifluoromethyl)sulphonimidoyl]benzenecarboximide amide; In N,N-dimethyl-formamide; at 20 - 150 ℃; for 1h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-2H-pyrazole-3-carboxylate

: 1227300-02-8
N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 18 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

2.2: pH 3

3.1: 150 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 - 150 °C

With potassium tert-butylate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 1227300-02-8
N-(3,4-Dimethoxybenzyl)-N-methyl-5-{[5-methyl-3-(3-{4-[S-(trifluoromethyl)-sulphonimidoyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 18 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

2.2: pH 3

3.1: 150 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 - 150 °C

With potassium tert-butylate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;