1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

Base Information

Chemical Name:1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide
CAS No.:129797-24-6
Molecular Formula:C₂₀H₂₃N₅O₆S
Molecular Weight:461.499
Hs Code.:

Synonyms:1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

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Chemical Property of 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

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Technology Process of 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

There total 4 articles about 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 532-55-8
Benzoyl isothiocyanate

: 53762-14-4
5-amino-1-(2',3'O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carboxamide

: 129797-24-6
1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

Guidance literature:: In acetone; for 6h; Heating;
DOI:10.1002/jhet.5570270357

Reference yield:

: 532-55-8
Benzoyl isothiocyanate

: 55726-09-5
5-amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carbonitrile

: 129797-24-6
1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

Guidance literature:: 5-amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carbonitrile; With ammonium hydroxide; dihydrogen peroxide; In methanol; water; at 25 ℃; for 16h;

Benzoyl isothiocyanate; In acetone; at 25 - 60 ℃; for 4h;

Reference yield:

: 532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7
D-Ribose

: 129797-24-6
1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 12 h / 27 °C

2.1: hydrazine hydrate / methanol / 2 h / 25 °C

2.2: 0.5 h / 78 °C

3.1: ammonium hydroxide; dihydrogen peroxide / water; methanol / 16 h / 25 °C

3.2: 4 h / 25 - 60 °C

With ammonium hydroxide; sulfuric acid; dihydrogen peroxide; hydrazine hydrate; In methanol; water;