3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

Base Information

Chemical Name:3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate
CAS No.:1582263-03-3
Molecular Formula:C₂HF₃O₂*C₁₇H₁₇FN₂O₃S
Molecular Weight:462.422
Hs Code.:

Synonyms:3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

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Chemical Property of 3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

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Technology Process of 3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

There total 5 articles about 3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582263-01-1
(4S,5R)-tert-butyl 5-(4-(6-(1,1-dioxido-2H-thiet-3-yl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidine-3-carboxylate

: 76-05-1
trifluoroacetic acid

: 1582263-03-3
3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1207758-79-9
3-(5-bromopyridin-2-yl)thietan-3-ol

: 1582263-03-3
3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethanol / 6 h / 80 °C / Inert atmosphere

4: dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamino-sulfur trifluoride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 1582262-99-4
3-(5-bromopyridin-2-yl)-3-hydroxythietane1,1-dioxide

: 1582263-03-3
3-(5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)-2H-thiete 1,1-dioxide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene; ethanol / 6 h / 80 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamino-sulfur trifluoride; sodium carbonate; In ethanol; dichloromethane; water; toluene;