4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

Base Information

Chemical Name:4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide
CAS No.:1143578-35-1
Molecular Formula:C₂₀H₁₈F₂N₆O
Molecular Weight:396.399
Hs Code.:

Synonyms:4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

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Chemical Property of 4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

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Technology Process of 4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

There total 6 articles about 4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 887624-77-3
2,2,2-trichloroethyl pyridazin-3-ylcarbamate

: 1-[4-(2,4-difluorophenyl)pyridin-2-yl]piperazine dihydrochloride

: 1143578-35-1
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

Guidance literature:: 1-[4-(2,4-difluorophenyl)pyridin-2-yl]piperazine dihydrochloride; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

2,2,2-trichloroethyl pyridazin-3-ylcarbamate; In dimethyl sulfoxide; at 45 ℃; for 12h;

Reference yield: 31.0%

: 887624-77-3
2,2,2-trichloroethyl pyridazin-3-ylcarbamate

: 1143623-60-2
1-[4-(2,4-difluorophenyl)pyridin-2-yl]piperazine

: 1143578-35-1
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 70 ℃;
DOI:10.1016/j.bmc.2013.12.023

Reference yield:

: 144025-03-6
2,4-difluorophenylboronic acid

: 1143578-35-1
4-[4-(2,4-difluorophenyl)pyridin-2-yl]-N-(pyridazin-3-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 17 h / 20 - 50 °C / Inert atmosphere

2: sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 85 °C

3: hydrogenchloride / methanol / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 70 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In 1,4-dioxane; methanol; dimethyl sulfoxide; 1: |Suzuki Coupling / 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.023