(5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester

Base Information

• Chemical Name: (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester
• CAS No.: 112682-06-1
• Molecular Formula: C₃₃H₄₆O₆S
• Molecular Weight: 570.791
• Mol file: 112682-06-1.mol

Synonyms:(5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester

Chemical Property of (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester

There total 3 articles about (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5S,6S,7Z)-methyl 5,6-oxido-9-(4-heptylphenyl)-7-nonenoate (104948-09-6) + methyl 4-(mercaptomethyl)-3-methoxybenzoate (112682-05-0) → (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester (112682-06-1)

Guidance literature:

With triethylamine; In methanol;

DOI:10.1021/jm00398a033

Reference yield:

methyl 4-methyl-3-methoxybenzoate (3556-83-0) → (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester (112682-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / bromine / CCl₄ / 4 h / Heating; Irradiation

2: 66 percent / thiolacetic acid, potassium carbonate / methanol / 1.) 5 deg C, 10 min, 2.) room temperatre

3: 89 percent / triethylamine / methanol

With bromine; potassium carbonate; triethylamine; tiolacetic acid; In methanol; tetrachloromethane;

DOI:10.1021/jm00398a033

Reference yield:

methyl 4-(bromomethyl)-3-methoxybenzoate (70264-94-7) → (5S,6R,7Z)-6-<<(4-carbomethoxy-2-methoxyphenyl)methyl>thio>-5-hydroxy-9-(4-heptylphenyl)-7-nonenoic acid methyl ester (112682-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / thiolacetic acid, potassium carbonate / methanol / 1.) 5 deg C, 10 min, 2.) room temperatre

2: 89 percent / triethylamine / methanol

With potassium carbonate; triethylamine; tiolacetic acid; In methanol;

DOI:10.1021/jm00398a033

upstream raw materials:

(5S,6S,7Z)-methyl 5,6-oxido-9-(4-heptylphenyl)-7-nonenoate

methyl 4-(mercaptomethyl)-3-methoxybenzoate

methyl 4-methyl-3-methoxybenzoate

methyl 4-(bromomethyl)-3-methoxybenzoate