cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

Base Information

Chemical Name:cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone
CAS No.:82323-36-2
Molecular Formula:C₁₉H₁₈O₂
Molecular Weight:278.351
Hs Code.:

Synonyms:cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

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Chemical Property of cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

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Technology Process of cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

There total 8 articles about cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 82323-35-1
1-methyl-3-phenyl-3-butenyl 2-diazophenylacetate

: 82323-36-2
cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

Guidance literature:: With copper; In benzene; for 1h; Heating;
DOI:10.1021/jo00139a002

Reference yield:

: 3360-52-9
3-chloro-2-phenylprop-1-ene

: 82323-36-2
cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg / 1.) THF, reflux, 2.) 0 deg C, 15 min

2: 93.4 percent / triethylamine / CH₂Cl₂ / 6 h / 0 deg C to 25 deg C

3: 85.1 percent / copper-bronze / benzene / 1 h / Heating

With copper; magnesium; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo00139a002

Reference yield:

: 6006-81-1
3-hydroxy-2-phenylpropene

: 82323-36-2
cis-2-(2-hydroxypropyl)-1,2-diphenylcyclopropane-1-carboxylic acid lactone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiCl, 2.) methanesulfonyl chloride / 1.) s-collidine, DMF, 0 deg C, 2.) 0 to 25 deg C, 8 h

2: 1.) Mg / 1.) THF, reflux, 2.) 0 deg C, 15 min

3: 93.4 percent / triethylamine / CH₂Cl₂ / 6 h / 0 deg C to 25 deg C

4: 85.1 percent / copper-bronze / benzene / 1 h / Heating

With copper; magnesium; methanesulfonyl chloride; triethylamine; lithium chloride; In dichloromethane; benzene;
DOI:10.1021/jo00139a002