9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Base Information

Chemical Name:9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine
CAS No.:1013663-64-3
Molecular Formula:C₂₅H₁₈ClN₃O₃S₂
Molecular Weight:508.021
Hs Code.:

Synonyms:9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

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Chemical Property of 9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

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Technology Process of 9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

There total 6 articles about 9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75-15-0,12122-00-8
carbon disulfide

: 579443-26-8
C₂₄H₂₀ClN₃O₃S

: 1013663-64-3
9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: With pyridine; for 48h; Heating;
DOI:10.1080/10426500601096369

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1013663-64-3
9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / ethanol / Heating

2: 88 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 94 percent / sodium ethoxide / ethanol / 0.08 h / Heating

4: 78 percent / pyridine / 48 h / Heating

With piperidine; pyridine; sodium ethanolate; sodium acetate; In ethanol; 3: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500601096369

Reference yield:

: 97651-28-0
ethyl 4-(4'-chlorophenyl)-3-cyano-6-methyl-1,2-dihydropyridine-5-carboxylate

: 1013663-64-3
9-(4-chlorophenyl)-8-ethoxycarbonyl-7-methyl-4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxopyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 94 percent / sodium ethoxide / ethanol / 0.08 h / Heating

3: 78 percent / pyridine / 48 h / Heating

With pyridine; sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500601096369