[(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid

Base Information

• Chemical Name: [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid
• CAS No.: 207726-14-5
• Molecular Formula: C₃₁H₃₄N₆O₈
• Molecular Weight: 618.646
• Mol file: 207726-14-5.mol

Synonyms:[(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid

Chemical Property of [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid

There total 10 articles about [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

[(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.02,7]dodec-4-yl]-acetic acid methyl ester (207726-13-4) → [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.02,7]dodec-4-yl]-acetic acid (207726-14-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; Ambient temperature;

DOI:10.1002/(SICI)1099-0690(199805)1998:5<853::AID-EJOC853>3.0.CO;2-F

Reference yield:

4-aminobenzamidine dihydrochloride (2498-50-2) → [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.02,7]dodec-4-yl]-acetic acid (207726-14-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 50 percent / 5N NaOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

2: 1.) DCC; 2.) DMAP, NEt₃ / 1.) dichloromethane, 0 deg C, 1 h; 2.) dichloromethane, r.t., 15 h

3: 74 percent / TFA / CH₂Cl₂

4: 31 percent / DCC, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

5: 73 percent / NaOH / dioxane; H₂O / Ambient temperature

With dmap; sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1002/(SICI)1099-0690(199805)1998:5<853::AID-EJOC853>3.0.CO;2-F

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → [(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.02,7]dodec-4-yl]-acetic acid (207726-14-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 50 percent / 5N NaOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

2: 1.) DCC; 2.) DMAP, NEt₃ / 1.) dichloromethane, 0 deg C, 1 h; 2.) dichloromethane, r.t., 15 h

3: 74 percent / TFA / CH₂Cl₂

4: 31 percent / DCC, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

5: 73 percent / NaOH / dioxane; H₂O / Ambient temperature

With dmap; sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1002/(SICI)1099-0690(199805)1998:5<853::AID-EJOC853>3.0.CO;2-F

upstream raw materials:

[(4S,7S)-5-({[(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-methyl]-carbamoyl}-methyl)-3,6-dioxo-2,5-diaza-tricyclo[6.2.2.0^2,7]dodec-4-yl]-acetic acid methyl ester

4-aminobenzamidine dihydrochloride

benzyl chloroformate

cyclo-(-Asp-Abo-)