8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

Base Information

Chemical Name:8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid
CAS No.:106017-02-1
Molecular Formula:C₂₃H₂₃N₃O₃S
Molecular Weight:421.52
Hs Code.:

Synonyms:8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

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Chemical Property of 8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

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Technology Process of 8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

There total 5 articles about 8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.3%

: 2759-28-6
1-phenylmethylpiperazine

: 106016-92-6
9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid

: 106017-02-1
8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

Guidance literature:: In N,N,N,N,N,N-hexamethylphosphoric triamide; at 150 ℃; for 3h;
DOI:10.1021/jm00386a005

Reference yield:

: 348-40-3
2-amino-6-fluoro-1,3-benzothiazole

: 106017-02-1
8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 50 percent NaOH / 1.) reflux, 24 h, 2.) water, reflux, 1 h

2: LiAlH₄ / tetrahydrofuran / 1 h / Ambient temperature

3: 2.) polyphosphoric acid / 1.) 120 deg C, 2 h, 2.) 160 deg C, 1 h

4: 92 percent / 15 percent NaOH / 0.75 h / Heating

5: 52.3 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

With sodium hydroxide; lithium aluminium tetrahydride; PPA; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00386a005

Reference yield:

: 106016-85-7
7-Fluoro-3,4-dihydro-2H-benzo[1,4]thiazine

: 106017-02-1
8-(4-Benzyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) polyphosphoric acid / 1.) 120 deg C, 2 h, 2.) 160 deg C, 1 h

2: 92 percent / 15 percent NaOH / 0.75 h / Heating

3: 52.3 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C

With sodium hydroxide; PPA; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00386a005