3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

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Chemical Name:3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester
CAS No.:160428-82-0
Molecular Formula:C₂₇H₂₉BrF₂N₂O₄
Molecular Weight:563.439
Hs Code.:

Synonyms:3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

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Chemical Property of 3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

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Technology Process of 3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

There total 2 articles about 3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,4,6-trimethylphenyl diethylphosphonoacetate

: 160428-82-0
3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaN(TMS)2 / tetrahydrofuran / 1 h

2: 1.) LDA; 2.) Et₃B, O₂ / 1.) THF, -78 deg C, 15 min; 2.) THF, 1,3-dimethyl-2-imidazolidinone, -20 deg C, 3 h

With triethyl borane; oxygen; sodium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)75998-3

Reference yield:

: 158725-01-0
2,4,6-trimethylphenyl 4-bromo-4,4,-difluorocrotonate

: 1-Pent-4-enoyl-3-phenyl-imidazolidin-2-one

: [2,2-Difluoro-3-methyl-5-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-cyclopentyl]-acetic acid 2,4,6-trimethyl-phenyl ester

: (1R,3S)-2,2-Difluoro-3-[1-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-but-3-enyl]-cyclopropanecarboxylic acid 2,4,6-trimethyl-phenyl ester

: 160428-82-0
3-(Bromo-difluoro-methyl)-4-(2-oxo-3-phenyl-imidazolidine-1-carbonyl)-hept-6-enoic acid 2,4,6-trimethyl-phenyl ester

Guidance literature:: With triethyl borane; oxygen; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 15 min; 2.) THF, 1,3-dimethyl-2-imidazolidinone, -20 deg C, 3 h;
DOI:10.1016/S0040-4039(00)75998-3