(E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine

Base Information

• Chemical Name: (E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine
• CAS No.: 674781-08-9
• Molecular Formula: C₂₃H₂₅BrN₄O₇
• Molecular Weight: 549.378
• Mol file: 674781-08-9.mol

Synonyms:(E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine

Chemical Property of (E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine

There total 1 articles about (E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

benzyl chloroformate (501-53-1,94274-21-2) + (E)-5'-allyloxycarbonylamino-3'-amino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine (674780-98-4) → (E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine (674781-08-9)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 24h;

DOI:10.1021/jo035678m

Reference yield: 81.0%

(E)-5'-allyloxycarbonylamino-3'-benzyloxycarbonylamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine (674781-08-9) → (E)-5'-amino-3'-benzyloxycarbonylamino-5-(2-bromoallyl)-2',3',5'-trideoxyuridine

Guidance literature:

With tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo035678m

upstream raw materials:

benzyl chloroformate

(E)-5'-allyloxycarbonylamino-3'-amino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine