((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine

Base Information

• Chemical Name: ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine
• CAS No.: 66007-24-7
• Molecular Formula: C₁₈H₂₃N₂OPS
• Molecular Weight: 346.433

Synonyms:((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine

Chemical Property of ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine

Chemical Property:

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Technology Process of ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine

There total 2 articles about ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ⁵-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) → ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine (66007-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / thiophosphoryl trichloride

2: triethylamine / tetrahydrofuran / RT, 24 h, 65 deg C, 24 h

With trichlorothiophosphine; triethylamine; In tetrahydrofuran;

DOI:10.1021/ja00329a072

Reference yield:

(2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide (57651-34-0) + (S)-1-phenyl-ethylamine (2627-86-3) → ((2R,4S,5R)-3,4-Dimethyl-5-phenyl-2-thioxo-2λ5-[1,3,2]oxazaphospholidin-2-yl)-((S)-1-phenyl-ethyl)-amine (66007-24-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; Yield given; RT, 24 h, 65 deg C, 24 h;

DOI:10.1021/ja00329a072

upstream raw materials:

(2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide

(S)-1-phenyl-ethylamine

ephedrine

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