N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

Base Information

Chemical Name:N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide
CAS No.:1121775-82-3
Molecular Formula:C₁₄H₁₉NO₄
Molecular Weight:265.309
Hs Code.:

Synonyms:N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

Chemical Property:

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Technology Process of N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

There total 6 articles about N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1121775-81-2
(E)-N-methoxy-N-methyl-3-(2,4-dimethoxyphenyl)-acrylamide

: 70775-39-2,5367-24-8
dimethylsulfoxonium methylide

: 1121775-82-3
N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol802970g

Reference yield:

: 1121775-81-2
(E)-N-methoxy-N-methyl-3-(2,4-dimethoxyphenyl)-acrylamide

: 2181-42-2
trimethylsulphonium iodide

: 1121775-82-3
N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

Guidance literature:: trimethylsulphonium iodide; With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

(E)-N-methoxy-N-methyl-3-(2,4-dimethoxyphenyl)-acrylamide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201102583

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1121775-82-3
N-methoxy-N-methyl-1-[2-(2,4-dimethoxyphenyl)-cyclopropan-1-yl]-formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-amino propanoic acid / pyridine / 1.5 h / Reflux; Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.42 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

2.3: 6 h / 0 - 23 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; n-butyllithium; 3-amino propanoic acid; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1002/chem.201102583