5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

Base Information

• Chemical Name: 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide
• CAS No.: 1025998-60-0
• Molecular Formula: C₁₇H₁₃N₃OS
• Molecular Weight: 307.376

Synonyms:5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

Chemical Property of 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

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Technology Process of 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

There total 3 articles about 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-2,3-dihydro-1H-indole-5-carbonitrile (61394-50-1) → 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide (1025998-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / H₂O / Heating

2: 41 percent / Na₂CO₃, P₂S₅ / tetrahydrofuran / Ambient temperature

3: 1.) NaH / 1.) THF, 2.) THF

With sodium hydroxide; tetraphosphorus decasulfide; sodium hydride; sodium carbonate; In tetrahydrofuran; water;

DOI:10.1021/jm00039a016

Reference yield:

1-methyl-5-cyan-1,3-dihydroindol-2-one (156136-72-0) → 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide (1025998-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Na₂CO₃, P₂S₅ / tetrahydrofuran / Ambient temperature

2: 1.) NaH / 1.) THF, 2.) THF

With tetraphosphorus decasulfide; sodium hydride; sodium carbonate; In tetrahydrofuran;

DOI:10.1021/jm00039a016

Reference yield:

phenyl isocyanate (103-71-9) + 5-cyano-1-methyl-2-indolinethione (156136-73-1) → 5-Cyano-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide (1025998-60-0)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) THF, 2.) THF;

DOI:10.1021/jm00039a016

upstream raw materials:

phenyl isocyanate

5-cyano-1-methyl-2-indolinethione

2-oxo-2,3-dihydro-1H-indole-5-carbonitrile

1-methyl-5-cyan-1,3-dihydroindol-2-one

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