diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

Base Information

Chemical Name:diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate
CAS No.:1415110-33-6
Molecular Formula:C₂₁H₂₆N₂O₉
Molecular Weight:450.445
Hs Code.:

Synonyms:diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

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Chemical Property of diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

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Technology Process of diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

There total 5 articles about diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1415110-31-4
diethyl 3-[(4-nitrophenyl)carbamoyl]cyclopropane-1,2-dicarboxylate

: 1415110-33-6
diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1002/ejoc.201200730

Reference yield:

: 4338-06-1
N-(4-nitrophenyl)maleimide

: 1415110-33-6
diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / 1 h / 65 °C

2: triethylamine / 0.67 h / Microwave irradiation

3: dmap; triethylamine / dichloromethane / 1 h / 0 °C

With dmap; triethylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/ejoc.201200730

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 1415110-33-6
diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 1.5 h / 20 °C

2: sodium acetate; acetic anhydride / 4 h / 100 °C

3: 1,2-dichloro-ethane / 1 h / 65 °C

4: triethylamine / 0.67 h / Microwave irradiation

5: dmap; triethylamine / dichloromethane / 1 h / 0 °C

With dmap; sodium acetate; acetic anhydride; triethylamine; In dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1002/ejoc.201200730