(1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol

Base Information

• Chemical Name: (1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol
• CAS No.: 144788-29-4
• Molecular Formula: C₁₃H₁₆F₂O₂S
• Molecular Weight: 274.332

Synonyms:(1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol

Chemical Property of (1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol

There total 4 articles about (1S,3S,5R,R_S)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

(2R,3R,RS)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulfinyl>hex-5-en-1-ol (144788-13-6) → (1S,3R,5R,RS)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol (144788-24-9) + (1S,3S,5R,RS)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol (144788-29-4)

Guidance literature:

With tri-n-butyl-tin hydride; In benzene; at 35 ℃; for 0.0666667h; Irradiation;

DOI:10.1016/S0040-4020(01)86600-X

Reference yield:

(-)-menthyl p-toluenesulfinate (1517-82-4) → (1S,3S,5R,RS)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol (144788-29-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) Mg, I₂ / 1) ether, 2h, 2) benzene, RT, 30 min

2: 1) LDA / 1) THF, 3 min, 2) THF, -65 deg C, 5 min

3: 13.3 percent / NaBH₄, aq. NH₃ / methanol / 0.17 h / -20 °C

4: 69.9 percent / Bu₃SnH / benzene / 0.07 h / 35 °C / Irradiation

With ammonium hydroxide; sodium tetrahydroborate; iodine; tri-n-butyl-tin hydride; magnesium; lithium diisopropyl amide; In methanol; benzene;

DOI:10.1016/S0040-4020(01)86600-X

Reference yield:

(R)-1-(but-3-ene-1-sulfinyl)-4-methyl-benzene (115878-98-3) → (1S,3S,5R,RS)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfinyl>cyclopentan-1-ol (144788-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) LDA / 1) THF, 3 min, 2) THF, -65 deg C, 5 min

2: 13.3 percent / NaBH₄, aq. NH₃ / methanol / 0.17 h / -20 °C

3: 69.9 percent / Bu₃SnH / benzene / 0.07 h / 35 °C / Irradiation

With ammonium hydroxide; sodium tetrahydroborate; tri-n-butyl-tin hydride; lithium diisopropyl amide; In methanol; benzene;

DOI:10.1016/S0040-4020(01)86600-X

upstream raw materials:

(2R,3R,R_S)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulfinyl>hex-5-en-1-ol

(-)-menthyl p-toluenesulfinate

(R)-1-(but-3-ene-1-sulfinyl)-4-methyl-benzene

(R_S)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulfinyl>hex-5-en-2-one

Downstream raw materials:

(1S,3S,5R)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfenyl>cyclopentan-1-ol

(1S,3S,5R)-2,2-difluoro-3-methyl-5-<(4-methylphenyl)sulfenyl>cyclopentan-1-ol benzoate

(1S,2S,3R,5S)-3-benzyloxy-4,4-difluoro-5-methylcyclopentan-1,2-diol

(1R,3S)-2,2-difluoro-3-methylcyclopentan-1-ol benzoate

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