4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

Base Information

Chemical Name:4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine
CAS No.:237435-62-0
Molecular Formula:C₂₀H₂₄N₄
Molecular Weight:320.437
Hs Code.:

Synonyms:4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

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Technology Process of 4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

There total 5 articles about 4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 536-74-3
phenylacetylene

: 237435-61-9
4-((6S,2R)-2,6-dimethylpiperidyl)-6-chloro-2-methylpyrimidin-5-ylamine

: 237435-62-0
4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 70 ℃;
DOI:10.1021/jm000269t

Reference yield:

: 13162-43-1
4,6-dichloro-2-methyl-5-nitropyrimidine

: 237435-62-0
4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Et₃N / tetrahydrofuran / 72 h / 20 °C

2: 40 percent / SnCl₂*H₂O; conc. aq. HCl / diethyl ether / 3 h / 20 °C

3: 95 percent / Et₃N; Pd(PPh₃)2Cl₂; CuI / 70 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; tin(ll) chloride; In tetrahydrofuran; diethyl ether; 3: Heck reaction;
DOI:10.1021/jm000269t

Reference yield:

: 1194-22-5
2-methyl-4,6-dihydroxypyrimidine

: 237435-62-0
4-((6S,2R)-2,6-dimethylpiperidyl)-2-methyl-6-(2-phenylethynyl)pyrimidin-5-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / TFA; 90percent aq. HNO₃ / 12 h / 20 °C

2: 49 percent / POCl₃; diisopropylethylamine / toluene / 3 h / Heating

3: 84 percent / Et₃N / tetrahydrofuran / 72 h / 20 °C

4: 40 percent / SnCl₂*H₂O; conc. aq. HCl / diethyl ether / 3 h / 20 °C

5: 95 percent / Et₃N; Pd(PPh₃)2Cl₂; CuI / 70 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tin(ll) chloride; trichlorophosphate; In tetrahydrofuran; diethyl ether; toluene; 5: Heck reaction;
DOI:10.1021/jm000269t