7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Base Information

Chemical Name:7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one
CAS No.:1419829-29-0
Molecular Formula:C₃₁H₃₄N₂O₄
Molecular Weight:498.622
Hs Code.:

Synonyms:7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

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Chemical Property of 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

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Technology Process of 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

There total 9 articles about 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 104-58-5
3-piperidinopropan-1-ol

: 2-(4-bromophenyl)-7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one

: 1419829-29-0
7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In N,N-dimethyl-formamide; at 110 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.8b03653

Reference yield: 39.0%

: 1419827-39-6
2-(4-hydroxyphenyl)-7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one

: 5472-49-1
1-(3-chloropropyl)piperidine hydrochloride

: 1419829-29-0
7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Guidance literature:: With potassium carbonate; potassium iodide; In acetone; for 12h; Reflux;
DOI:10.1016/j.bmcl.2014.03.042

Reference yield:

: 4-methoxy-7-(4-methoxyphenyl)bicyclo[4.2.0]octa-1,3,5-trien-7-ol

: 2493-02-9
4-bromophenyl isocyanate

: 1419829-29-0
7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: [Rh(OH)(cod)]2 / 1,2-dichloro-ethane / 5 h / 50 °C / Schlenk technique; Inert atmosphere; Sealed tube

1.2: 0.5 h / 20 °C / Schlenk technique; Inert atmosphere; Sealed tube

2.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 8 h / 110 °C / Schlenk technique; Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; [Rh(OH)(cod)]2; caesium carbonate; XPhos; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.8b03653