(S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester

Base Information

• Chemical Name: (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester
• CAS No.: 215163-35-2
• Molecular Formula: C₆₅H₆₈N₂O₁₁
• Molecular Weight: 1053.26
• Mol file: 215163-35-2.mol

Synonyms:(S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester

Chemical Property of (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester

There total 2 articles about (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl L-glutamate (2768-50-5) → (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester (215163-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.17 h / Ambient temperature

2: tetrahydrofuran / Ambient temperature

In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(98)00422-3

Reference yield:

phenethyl isocyanide (59795-89-0) + (S)-2-Eth-(E)-ylideneamino-pentanedioic acid dibenzyl ester + ((2R,3R,4R,5R,6R)-3,4,5-Tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetic acid → (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester (215163-35-2)

Guidance literature:

In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(98)00422-3

Reference yield:

(S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid dibenzyl ester (215163-35-2) → (S)-2-{(1-Phenethylcarbamoyl-ethyl)-[2-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-phenoxymethyl-tetrahydro-pyran-2-yl)-acetyl]-amino}-pentanedioic acid

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; under 760 Torr; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(98)00422-3

upstream raw materials:

phenethyl isocyanide

dibenzyl L-glutamate