2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester

Base Information

• Chemical Name: 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester
• CAS No.: 438623-65-5
• Molecular Formula: C₂₄H₂₃FN₂O₅
• Molecular Weight: 438.455
• Mol file: 438623-65-5.mol

Synonyms:2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester

Chemical Property of 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester

There total 10 articles about 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl)oxy]acetic acid methyl ester (438623-93-9) → 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester (438623-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 0.20 g / NH₃ / CH₂Cl₂; dioxane / 1 h

With ammonia; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm0401309

Reference yield:

[3-chlorooxalyl-1-(4-fluoro-benzyl)-2-methyl-1,6,7,8-tetrahydro-1-aza-as-indacen-4-yloxy]-acetic acid methyl ester → 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester (438623-65-5)

Guidance literature:

With ammonia; In 1,4-dioxane; dichloromethane; for 1h;

DOI:10.1021/jm0401309

Reference yield:

5-methoxyindane (5111-69-3) → 2-[[3-(2-Amino-1,2-dioxoethyl)-2-methyl-1-(4-fluorobenzyl)-1,6,7,8-tetrahydrocyclopent[g]indol-4-yl]oxy]acetic Acid Methyl Ester (438623-65-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: POCl₃ / 0.5 h / 0 °C

1.2: 73 percent / 4 h / 80 °C

2.1: 53 percent / NaOEt / diethyl ether; ethanol / 3 h / -10 - 20 °C

3.1: 52 percent / toluene / 6 h / Heating

4.1: NaH / 0.5 h / 20 °C

4.2: 74 percent / 42 h / 20 °C

5.1: 85 percent / LiAlH₄ / tetrahydrofuran / 20 h / 20 °C

6.1: 100 percent / NaBH₄; PdCl₂ / tetrahydrofuran; methanol / 1.5 h / 20 °C

7.1: BBr₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

8.1: 0.71 g / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

9.1: CH₂Cl₂ / 1.5 h / 0 - 20 °C

10.1: 0.20 g / NH₃ / CH₂Cl₂; dioxane / 1 h

With sodium tetrahydroborate; lithium aluminium tetrahydride; ammonia; sodium ethanolate; boron tribromide; sodium hydride; caesium carbonate; palladium dichloride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.2: Vilsmeier reaction;

DOI:10.1021/jm0401309

upstream raw materials:

5-methoxyindane

2,3-dihydro-6-methoxy-1H-indene-5-carboxaldehyde

2-carboethoxy-4-methoxy-1,6,7,8-tetrahydrocyclopent[g]indole

3-(2,3-dihydro-6-methoxy-1H-inden-5-yl)-2-azido-2-propenoic acid ethyl ester