3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Base Information

Chemical Name:3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester
CAS No.:1415743-33-7
Molecular Formula:C₂₈H₂₉F₃N₄O₆S
Molecular Weight:606.623
Hs Code.:

Synonyms:3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

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Chemical Property of 3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

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Technology Process of 3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

There total 6 articles about 3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415743-31-5
3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

: 456-27-9
4-nitrobenzenediazonium tetrafluoroborate

: 1415743-33-7
3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: With sulfuric acid; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/jo302065u

Reference yield:

: 1415743-29-1
3-iodopropane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

: 1415743-33-7
3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

2: sulfuric acid / water; methanol / 1 h / 20 °C

With sulfuric acid; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo302065u

Reference yield:

: (±)-trimethyl(2,2,2-trifluoro-1-(4-methylphenyl)ethoxy)silane

: 1415743-33-7
3-[7-methoxy-6-(4-nitrophenylazo)-3,4-dihydro-2H-quinolin-1-yl]propane-1-sulfonic acid 2,2,2-trifluoro-1-p-tolyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

2: triethylamine / dichloromethane / 0 - 4 °C

3: sodium iodide / acetone / 16 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

5: sulfuric acid / water; methanol / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo302065u