7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

Base Information

Chemical Name:7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine
CAS No.:926035-09-8
Molecular Formula:C₁₉H₂₀ClNO₄S
Molecular Weight:393.891
Hs Code.:

Synonyms:7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

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Chemical Property of 7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

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Technology Process of 7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

There total 1 articles about 7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 107-30-2
chloromethyl methyl ether

: 193686-76-9
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 926035-09-8
7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

Guidance literature:: 7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at -78 ℃; for 1h;

chloromethyl methyl ether; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.3987/COM-06-S(O)42

Reference yield: 79.0%

: 926035-09-8
7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

: trans-7-chloro-4-hydroxy-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: 7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine; With borane-THF; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 7.5h; Further stages.;
DOI:10.3987/COM-06-S(O)42

Reference yield:

: 926035-09-8
7-chloro-5-methoxymethoxy-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

: (4R,5R)-4,5-bis(methoxymethoxy)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃-THF / tetrahydrofuran / 20 °C

1.2: 79 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 7.5 h / 20 °C

2.1: 47 percent / isopropyl ether; Lipase QLM / 24 h / 65 °C

3.1: 98 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

4.1: 97 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Heating

5.1: 97 percent / sodium acetate; H₂ / Pd/C / ethanol / 4 h / 20 °C / 760.05 Torr

With sodium hydroxide; borane-THF; Lipase QLM; di-isopropyl ether; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.3987/COM-06-S(O)42