1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine

Base Information

• Chemical Name: 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine
• CAS No.: 353276-51-4
• Molecular Formula: C₂₃H₃₄N₂O₅
• Molecular Weight: 418.533
• Mol file: 353276-51-4.mol

Synonyms:1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine

Chemical Property of 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine

There total 8 articles about 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-{[tert-butoxycarbonyl-(4-hydroxy-butyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester (714250-21-2) → 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine (353276-51-4)

Guidance literature:

DOI:10.1016/S0960-894X(01)00170-6

Reference yield:

4-Aminomethylpiperidine (7144-05-0) → 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine (353276-51-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 61 percent / 1 h / 170 °C

2: 74 percent / NaOH / CH₂Cl₂; H₂O / 1 h / 20 °C

3: 100 percent / hydrazine monohydrate / ethanol / 80 °C

4: KF-Celite / acetonitrile / 50 °C

5: CH₂Cl₂ / 20 °C

6: 100 percent / K₂CO₃ / methanol / 20 °C

7: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With potassium fluoride; sodium hydroxide; oxalyl dichloride; potassium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; In methanol; ethanol; dichloromethane; water; acetonitrile; 7: Swern oxidation;

DOI:10.1016/S0968-0896(01)00398-4

Reference yield:

4-[(4-acetoxy-butylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester → 1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine (353276-51-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 °C

2: 100 percent / K₂CO₃ / methanol / 20 °C

3: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; 3: Swern oxidation;

DOI:10.1016/S0968-0896(01)00398-4

upstream raw materials:

4-{[tert-butoxycarbonyl-(4-hydroxy-butyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester

4-Aminomethylpiperidine

4-aminomethyl-piperidine-1-carboxylic acid benzyl ester

N-(1-benzyloxycarbonylpiperidin-4-ylmethyl)phthalimide