2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

Base Information

Chemical Name:2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester
CAS No.:916885-64-8
Molecular Formula:C₂₂H₂₆N₂O₆
Molecular Weight:414.458
Hs Code.:

Synonyms:2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

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Chemical Property of 2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

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Technology Process of 2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

There total 1 articles about 2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 916885-58-0
[(4-methoxybenzyl)(pyridine-4-carbonyl)amino]acetic acid tert-butyl ester

: 79-22-1
methyl chloroformate

: 916885-64-8
2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

Guidance literature:: [(4-methoxybenzyl)(pyridine-4-carbonyl)amino]acetic acid tert-butyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; at -20 ℃; for 0.0333333h;

methyl chloroformate; In tetrahydrofuran; at -20 - 20 ℃;
DOI:10.1021/ol062126s

Reference yield: 85.0%

: 916885-64-8
2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

: 2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nonane-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In isopropyl alcohol; at 50 ℃;
DOI:10.1021/ol062126s

Reference yield:

: 916885-64-8
2-(4-methoxybenzyl)-3-oxo-2,7-diazaspiro[3.5]nona-5,8-diene-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

: 3-oxo-2,7-diazaspiro[3.5]nonane-1,7-dicarboxylic acid 1-tert-butyl ester 7-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂ / Pd/C / propan-2-ol / 50 °C

2: 70 percent / Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O

With ammonium cerium(IV) nitrate; hydrogen; palladium on activated charcoal; In water; isopropyl alcohol; acetonitrile;
DOI:10.1021/ol062126s