4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Base Information

Chemical Name:4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid
CAS No.:1332713-17-3
Molecular Formula:C₁₈H₁₆FN₃O₄S
Molecular Weight:389.407
Hs Code.:

Synonyms:4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

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Chemical Property of 4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

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Technology Process of 4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

There total 4 articles about 4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{4-Fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

: 1332713-17-3
4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: 4-{4-Fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; With water; sodium hydroxide; In methanol;

With hydrogenchloride;

Reference yield:

: 1332713-16-2
4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

: 1332713-17-3
4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: 4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester; With methanol; sodium hydroxide;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 1332712-39-6
(R)-3-(5-fluoro-2-nitrophenoxy)tetrahydrofuran

: 1332713-17-3
4-{4-fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / Raney nickel / methanol / 20 °C

2.1: toluene-4-sulfonic acid / 1,4-dioxane / 110 °C / Microwave irradiation

3.1: sodium hydroxide; methanol

3.2: pH 7

With methanol; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; Raney nickel; In 1,4-dioxane; methanol;