[4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin

Base Information

• Chemical Name: [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin
• CAS No.: 664351-48-8
• Molecular Formula: C₈₈H₇₆O₁₃
• Molecular Weight: 1341.56
• Mol file: 664351-48-8.mol

Synonyms:[4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin

Chemical Property of [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin

There total 5 articles about [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5,7,3',4'-tetra-O-benzylepicatechin (87292-49-7) + (2R,3S,4S)-5,7,3',4'-tetrabenzyloxy-3-acetoxy-4-methoxyflavan (476312-04-6) → [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin (664351-48-8)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 2h; optical yield given as %de; Inert atmosphere;

DOI:10.2174/157017812800233697

Reference yield: 60.0%

5,7,3',4'-tetra-O-benzylepicatechin (87292-49-7) + (2R,3S,4S)-3-acetoxy-5,7,3',4'-tetrabenzyloxy-4-(2-ethoxyethoxy)flavan (664351-41-1) → [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin (664351-48-8)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 4h; optical yield given as %de; Inert atmosphere;

DOI:10.2174/157017812800233697

Reference yield: 54.0%

C47H44O8 (1234682-03-1) + 5,7,3',4'-tetra-O-benzylepicatechin (87292-49-7) → [4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-3-O-acetyl-(+)-catechin-(-)-epicatechin (664351-48-8)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 4h; optical yield given as %de; Inert atmosphere;

DOI:10.2174/157017812800233697

upstream raw materials:

5,7,3',4'-tetra-O-benzylepicatechin

(2R,3S,4S)-3-acetoxy-5,7,3',4'-tetrabenzyloxy-4-(2-ethoxyethoxy)flavan

(2R,3S,4S)-5,7,3',4'-tetrabenzyloxy-3-acetoxy-4-methoxyflavan

C₄₇H₄₄O₈

Downstream raw materials:

procyanidin B₄

[4,8']-2,3-trans-3,4-trans:2',3'-cis-octa-O-benzyl-(+)-catechin-(-)-epicatechin