Estazolam

Base Information Edit

Chemical Name:Estazolam
CAS No.:29975-16-4
Molecular Formula:C16H11ClN4
Molecular Weight:294.743
Hs Code.:2933910000
European Community (EC) Number:249-982-4
NSC Number:290818
UNII:36S3EQV54C
DSSTox Substance ID:DTXSID5020572
Nikkaji Number:J9.280K
Wikipedia:Estazolam
Wikidata:Q3045264
NCI Thesaurus Code:C47520
RXCUI:4077
Pharos Ligand ID:CNU5MATKV29X
Metabolomics Workbench ID:43428
ChEMBL ID:CHEMBL285674
Mol file:29975-16-4.mol

Synonyms:4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-phenyl- (8CI);8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;8-Chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;A 47631;Abbott 47631;Cannoc;D40TA;Esilgan;Eurodin;Julodin;NSC 290818;Nemurel;Nuctalon;ProSom;Somnatrol;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-phenyl-;

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Estazolam Edit

Chemical Property:

Appearance/Colour:fine, white, odorless powder
Vapor Pressure:9.55E-10mmHg at 25°C
Melting Point:228-229°
Refractive Index:1.728
Boiling Point:489.936 °C at 760 mmHg
PKA:pKa 2.84(H2O) (Uncertain)
Flash Point:250.105 °C
PSA：43.07000
Density:1.401 g/cm³
LogP:2.70730
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:294.0672241
Heavy Atom Count:21
Complexity:407

Purity/Quality:

Safty Information:

Pictogram(s): Xi, T, F
Hazard Codes:Xi,T,F
Statements: 36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 36/37/39-45-36/37-16-7

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Sedatives and Hypnotics
Canonical SMILES:C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4
Recent ClinicalTrials:Treatment of Chronic Insomnia According to Yin Yang Theory and Its Correlation With Circadian Rhythm
Recent EU Clinical Trials:Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
Description Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring . It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Uses A benzodiazepine derivative possessing anxiolytic, anticonvulsant, and muscle relaxant properties. It is commonly prescribed to treat short-term insomnia. Controlled Substance.
Therapeutic Function Hypnotic, Sedative

Technology Process of Estazolam

There total 5 articles about Estazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%