Technology Process of Ac-D-Leu-benzylamide
There total 3 articles about Ac-D-Leu-benzylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
di-μ-chlorobis(norbornadiene)dirhodium(I); (RP,RP)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane;
In
methanol;
under 760 Torr;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja00314a053
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 83 percent / KH, tert-butyl alcohol / tetrahydrofuran / Ambient temperature
2: H2 / (Rh(NBD)Cl)2, (R,R)-DIPAMP / methanol / 760 Torr
With
hydrogen; potassium hydride; tert-butyl alcohol;
di-μ-chlorobis(norbornadiene)dirhodium(I); (RP,RP)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00314a053
- Guidance literature:
-
Multi-step reaction with 3 steps
1: DBU, hematoporphyrin, oxygen / tetrahydrofuran / 2 h / 0 °C / Irradiation
2: 83 percent / KH, tert-butyl alcohol / tetrahydrofuran / Ambient temperature
3: H2 / (Rh(NBD)Cl)2, (R,R)-DIPAMP / methanol / 760 Torr
With
hydrogen; oxygen; potassium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; hematoporphyrin; tert-butyl alcohol;
di-μ-chlorobis(norbornadiene)dirhodium(I); (RP,RP)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00314a053