diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

Base Information

• Chemical Name: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate
• CAS No.: 94796-13-1
• Molecular Formula: C₃₀H₂₆N₂O₄S
• Molecular Weight: 510.613
• Mol file: 94796-13-1.mol

Synonyms:diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

Chemical Property of diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

There total 20 articles about diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tri-n-butyl(vinyl)tin (7486-35-3) + (6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (122553-60-0) → diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate (94796-13-1)

Guidance literature:

With triethylamine; palladium diacetate; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01940-6

Reference yield: 85.0%

Vinyl bromide (593-60-2,25951-54-6) + (6R,7R)-benzhydryl 3-chloro-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (63821-56-7) → diphenylmethyl (6R,7R)-7-(phenylacetamido)ceph-3-em-4-carboxylate (36923-19-0) + diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate (94796-13-1)

Guidance literature:

With (2,2'-bipyridine)nickel(II) dibromide; lead(II) bromide; aluminium; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

DOI:10.1021/jo001429b

Reference yield: 85.0%

tri-n-butyl(vinyl)tin (7486-35-3) + benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate (92096-37-2) → diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate (94796-13-1)

Guidance literature:

With lithium iodide; palladium diacetate; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01940-6

upstream raw materials:

tri-n-butyl(vinyl)tin

(6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate

Vinyl bromide

Downstream raw materials:

Benzhydryl 7-Phenylacetamido-3-(2',2'-diphenylcyclopropyl)-3-cephem-4-carboxylate

Benzhydryl 7-Phenylacetamido-3-(2',2'-diphenylcyclopropyl)-3-cephem-4-carboxylate

7-(phenylacetamido)-3-vinylcephem-4-carboxylic acid

4a-(4,5-Dihydro-3H-pyrazol-3-yl)-1-oxo-2-phenylacetylamino-2,2a,4a,5-tetrahydro-1H,4H-3-thia-6,7,7b-triaza-cyclobuta[e]indene-7a-carboxylic acid benzhydryl ester