N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide

Base Information

• Chemical Name: N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide
• CAS No.: 870640-38-3
• Molecular Formula: C₁₆H₁₇N₅O₃
• Molecular Weight: 327.343
• Mol file: 870640-38-3.mol

Synonyms:N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide

Chemical Property of N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide

There total 2 articles about N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

N-(2-amino-1-aminomethylethyl)benzamide (870640-37-2) + succinimidyl cyanoacetate (56657-76-2) → N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide (870640-38-3)

Guidance literature:

With triethylamine; In methanol; at 25 ℃;

DOI:10.1021/jm040208l

Reference yield:

(3-tert-butoxycarbonylamino-2-phenylacetylaminopropyl)carbamic acid tert-butyl ester (870640-36-1) → N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide (870640-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / tetrahydrofuran / 3 h / 20 °C

2: 28 percent / Et₃N / methanol / 25 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jm040208l

Reference yield: 28.0%

N-{2-(2-cyanoacetylamino)-1-[1-(2-cyanoacetylamino)methyl]ethyl}benzamide (870640-38-3) + 3,4-dihydroxybenzaldehyde (139-85-5) → N-(2-[(E)-2-Cyano-3-(3,4-dihydroxy-phenyl)-acryloylamino]-1-{[(E)-2-cyano-3-(3,4-dihydroxy-phenyl)-acryloylamino]-methyl}-ethyl)-benzamide

Guidance literature:

With piperidine; In ethanol; for 2h; Heating;

DOI:10.1021/jm040208l

upstream raw materials:

N-(2-amino-1-aminomethylethyl)benzamide

succinimidyl cyanoacetate

(3-tert-butoxycarbonylamino-2-phenylacetylaminopropyl)carbamic acid tert-butyl ester