5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Base Information

Chemical Name:5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide
CAS No.:1386984-45-7
Molecular Formula:C₂₁H₁₉F₄N₅O₂
Molecular Weight:449.408
Hs Code.:

Synonyms:5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

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Chemical Property of 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

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Technology Process of 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

There total 16 articles about 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386986-04-4
((R)-5-{5-[(5-cyano-3-methyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,2,5-tris-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamicacid tert-butyl ester

: 1386984-45-7
5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Guidance literature:: ((R)-5-{5-[(5-cyano-3-methyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,2,5-tris-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamicacid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 886365-43-1
5-bromo-3-methylpyridine-2-carboxylic acid

: 1386984-45-7
5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / tetrahydrofuran / 2 h / 20 °C

2: zinc / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

3: 1,3-Dimethoxybenzene; trifluoroacetic acid / 6.5 h

4: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h

With dmap; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 1,3-Dimethoxybenzene; zinc; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1356037-30-3
tert-butyl 5-bromo-3-methylpicolinate

: 1386984-45-7
5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: zinc / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 5 h / 60 °C / Inert atmosphere

2: 1,3-Dimethoxybenzene; trifluoroacetic acid / 6.5 h

3: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 1,3-Dimethoxybenzene; zinc; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tri-tert-butyl phosphine; In dichloromethane; N,N-dimethyl-formamide;