4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester

Base Information

• Chemical Name: 4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester
• CAS No.: 1228674-38-1
• Molecular Formula: C₁₇H₂₄BrNO₃
• Molecular Weight: 370.286

Synonyms:4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester

Chemical Property of 4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester

Chemical Property:

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Technology Process of 4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester

There total 1 articles about 4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-(3-oxo-propyl)-tetrahydro-pyran-4-carboxylic acid methyl ester (1228674-37-0) + 4-Bromo-2-methylaniline (583-75-5) → 4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester (1228674-38-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

Reference yield: 95.0%

4-[3-(4-bromo-2-methyl-phenylamino)-propyl]-tetrahydro-pyran-4-carboxylic acidmethyl ester (1228674-38-1) → 2-(4-bromo-2-methyl-phenyl)-9-oxa-2-aza-spiro[5.5]undecan-1-one (1228674-41-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 50 ℃; for 2h;

upstream raw materials:

4-(3-oxo-propyl)-tetrahydro-pyran-4-carboxylic acid methyl ester

4-Bromo-2-methylaniline

Downstream raw materials:

2-(4-bromo-2-methyl-phenyl)-9-oxa-2-aza-spiro[5.5]undecan-1-one

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