O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

Base Information

Chemical Name:O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine
CAS No.:592509-07-4
Molecular Formula:C₁₈H₂₁N₃O₂
Molecular Weight:311.384
Hs Code.:

Synonyms:O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

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Chemical Property of O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

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Technology Process of O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

There total 7 articles about O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374756-66-8
2-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyloxy}isoindole-1,3-dione

: 592509-07-4
O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

Guidance literature:: With methylhydrazine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1055/s-2001-16768

Reference yield:

: 2033-45-6
4-iodo-3,5-dimethyl-1H-pyrazole

: 592509-07-4
O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Et₃N / toluene / 8 h / Heating

2: 73 percent / piperidine; PPh₃ / PdCl₂(PPh₃)2; CuI / 24 h / 20 °C

3: 87 percent / PPh₃; DEAD / tetrahydrofuran / 48 h / 20 °C

4: CH₃NHNH₂ / CH₂Cl₂ / 4 h / 20 °C

With piperidine; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; toluene; 3: Mitsunobu reaction;
DOI:10.1055/s-2001-16768

Reference yield:

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 592509-07-4
O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / CAN; I₂

2: 92 percent / Et₃N / toluene / 8 h / Heating

3: 73 percent / piperidine; PPh₃ / PdCl₂(PPh₃)2; CuI / 24 h / 20 °C

4: 87 percent / PPh₃; DEAD / tetrahydrofuran / 48 h / 20 °C

5: CH₃NHNH₂ / CH₂Cl₂ / 4 h / 20 °C

With piperidine; ammonium cerium(IV) nitrate; iodine; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; toluene; 4: Mitsunobu reaction;
DOI:10.1055/s-2001-16768