1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one

Base Information

• Chemical Name: 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one
• CAS No.: 1283090-74-3
• Molecular Formula: C₁₈H₁₆ClFN₂O₂
• Molecular Weight: 346.789

Synonyms:1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one

Chemical Property of 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1''-Benzyl-6-Chloro-7-Fluoro-1h-Spiro[Furo[3,4-C]Pyridine-3,4''-Piperidin]-1-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one

There total 2 articles about 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) + 2-chloro-3-fluoro-pyridine-4-carboxylic acid (628691-93-0) → 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one (1283090-74-3)

Guidance literature:

2-chloro-3-fluoro-pyridine-4-carboxylic acid; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3.5h; Inert atmosphere;

1-phenylmethyl-4-piperidone; In tetrahydrofuran; at -78 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

2-chloro-3-fluoropyridine (17282-04-1) → 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one (1283090-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere

1.3: pH 2

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; diisopropylamine; In tetrahydrofuran;

Reference yield:

1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one (1283090-74-3) → 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-ol (1283090-75-4)

Guidance literature:

1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;

With water; In toluene; at 0 ℃;

upstream raw materials:

1-phenylmethyl-4-piperidone

2-chloro-3-fluoro-pyridine-4-carboxylic acid

2-chloro-3-fluoropyridine

Downstream raw materials:

1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-ol

7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]

N-[1-(3,4-difluorophenyl)-2,2-difluoro-1-{5-[(7-fluoro-1H,1'H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1'-yl)methyl]pyridin-2-yl}ethyl]acetamide

1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]

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