(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine
CAS No.:1429196-79-1
Molecular Formula:C₂₁H₂₃F₃N₄O₃S
Molecular Weight:468.5
Hs Code.:

Synonyms:(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

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Chemical Property of (7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

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Technology Process of (7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

There total 7 articles about (7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1086382-78-6
2-bromo-5-cyclopropylpyrazine

: 1429196-78-0
(7S,8aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

: 1429196-79-1
(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 481704-21-6
(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

: 1429196-79-1
(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 3 h / Reflux

2: triethylamine / 2-ethoxy-ethanol / 20 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4: hydrogen; 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 16 h / 50 °C / 1551.49 Torr

5: triethylamine / dichloromethane / 4 h / 20 °C

6: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

With lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; 2,2,2-trifluoroethanol; benzene;

Reference yield:

: 142347-81-7,441067-49-8
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

: 1429196-79-1
(7S,8aR)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 4 h / 0 - 25 °C

2: benzene / 3 h / Reflux

3: triethylamine / 2-ethoxy-ethanol / 20 h / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

5: hydrogen; 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 16 h / 50 °C / 1551.49 Torr

6: triethylamine / dichloromethane / 4 h / 20 °C

7: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; 2,2,2-trifluoroethanol; benzene;