2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester

Base Information

• Chemical Name: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester
• CAS No.: 241824-00-0
• Molecular Formula: C₃₉H₃₁NO₆
• Molecular Weight: 609.678
• Mol file: 241824-00-0.mol

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester

Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester

There total 3 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester (241823-98-3) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester (241824-00-0)

Guidance literature:

With N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾;

Reference yield:

9-bromo-9-phenyl-9H-fluorene (55135-66-5) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester (241824-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

2: 80 percent / PhNHMe / Pd(PPh₃)4

With N-ethyl-N,N-diisopropylamine; N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; 1: Alkylation / 2: Deallylation;

Reference yield:

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester (144120-54-7) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester (241824-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

2: 80 percent / PhNHMe / Pd(PPh₃)4

With N-ethyl-N,N-diisopropylamine; N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; 1: Alkylation / 2: Deallylation;

upstream raw materials:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

9-bromo-9-phenyl-9H-fluorene

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester

Downstream raw materials:

4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 9-phenyl-9H-fluoren-9-yl ester