3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

Base Information

Chemical Name:3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one
CAS No.:942157-21-3
Molecular Formula:C₃₅H₂₇N₃O₄
Molecular Weight:553.617
Hs Code.:

Synonyms:3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

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Chemical Property of 3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

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Technology Process of 3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

There total 7 articles about 3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 942157-04-2
3-(1-benzyl-1H-indole-2-carbonyl)oxazolidin-2-one

: 942157-21-3
3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

: 1,2-bis(1-benzyl-1H-indol-2-yl)ethane-1,2-dione

Guidance literature:: With samarium diiodide; In tetrahydrofuran; water; at -78 ℃; for 18h;
DOI:10.1021/jo070273d

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 942157-21-3
3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: HCl

2: NaH

3: NaOH / methanol; H₂O

4: 83 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

5: 70 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C

6: 71 percent / samarium(II) iodide / H₂O; tetrahydrofuran / 18 h / -78 °C

With hydrogenchloride; dmap; sodium hydroxide; n-butyllithium; samarium diiodide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo070273d

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 942157-21-3
3-(1-benzyl-3-(1-benzyl-1H-indole-2-carbonyl)-1H-indole-2-carbonyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: NaH

2: NaOH / methanol; H₂O

3: 83 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

4: 70 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C

5: 71 percent / samarium(II) iodide / H₂O; tetrahydrofuran / 18 h / -78 °C

With dmap; sodium hydroxide; n-butyllithium; samarium diiodide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo070273d