2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

Base Information

Chemical Name:2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide
CAS No.:934977-38-5
Molecular Formula:C₂₈H₃₈ClNO₅
Molecular Weight:504.066
Hs Code.:

2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-<i>N</i>,<i>N</i>-dimethyl-acetamide

Synonyms:2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

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Chemical Property of 2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

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Technology Process of 2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

There total 5 articles about 2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 934977-37-4
2-[1-(3-benzyloxy-propyl)-6-hydroxy-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

: 934977-38-5
2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

Guidance literature:: With tetrachloromethane; triphenylphosphine; for 2h; Heating;
DOI:10.1021/ja068346i

Reference yield:

: 934977-35-2
1-benzyloxy-5-(4-methoxy-benzyloxy)-9-(tetrahydro-pyran-2-yloxy)-non-7-en-4-ol

: 934977-38-5
2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

1.2: 100 percent / tetrahydrofuran / 4 h / 20 °C

2.1: 97 percent / ethanol / PTSA / 3 h / 20 °C

3.1: 92 percent / Ph₃P; CCl₄ / 2 h / Heating

With tetrachloromethane; ethanol; sodium hydride; triphenylphosphine; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1021/ja068346i

Reference yield:

: 934977-34-1
2-(4-methoxy-benzyloxy)-6-(tetrahydro-pyran-2-yloxy)-hex-4-enoic acid methyl ester

: 934977-38-5
2-[1-(3-benzyloxy-propyl)-6-chloro-2-(4-methoxy-benzyloxy)-hex-4-enyloxy]-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: DIBAL-H / diethyl ether; hexane / 0.5 h / -78 - 20 °C

1.2: 87 percent / diethyl ether; hexane / 12 h / -30 - -20 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

2.2: 100 percent / tetrahydrofuran / 4 h / 20 °C

3.1: 97 percent / ethanol / PTSA / 3 h / 20 °C

4.1: 92 percent / Ph₃P; CCl₄ / 2 h / Heating

With tetrachloromethane; ethanol; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja068346i