9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

Base Information

Chemical Name:9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine
CAS No.:132849-79-7
Molecular Formula:C₃₆H₄₁N₅O₄Si
Molecular Weight:635.838
Hs Code.:

Synonyms:9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

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Chemical Property of 9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

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Technology Process of 9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

There total 13 articles about 9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 132849-68-4
N⁶-<<2-(4-Nitrophenyl)ethoxy>carbonyl>-9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-3'-iodo-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

: 132849-79-7
9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

Guidance literature:: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; for 21h; Ambient temperature;
DOI:10.1002/hlca.19910740104

Reference yield: 75.0%

: 132849-77-5
N⁶-Benzoyl-9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

: 132849-79-7
9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; for 96h; Ambient temperature;
DOI:10.1002/hlca.19910740104

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 132849-79-7
9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-glycero-pent-3'-enofuranosyl>adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / 48 h / Ambient temperature

2: 81 percent / imidazole, pyridine / 48 h / Ambient temperature

3: 80 percent / DBU, pyridine / 24 h / Ambient temperature

4: 75 percent / conc. NH₃ / dioxane / 96 h / Ambient temperature

With pyridine; 1H-imidazole; ammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane;
DOI:10.1002/hlca.19910740104