toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

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Chemical Name:toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester
CAS No.:852158-07-7
Molecular Formula:C₁₅H₁₆N₂O₆S
Molecular Weight:352.368
Hs Code.:

Synonyms:toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

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Chemical Property of toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

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Technology Process of toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

There total 2 articles about toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 852158-06-6
C₂₂H₂₂N₂O₈S₂

: 852158-07-7
toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; In ethanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.tetlet.2005.02.128

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 852158-07-7
toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TEA / CH₂Cl₂ / 20 °C

2: 91 percent / aq. n-Bu₄NOH / ethanol / 0.25 h / 20 °C

With TEA; tetra(n-butyl)ammonium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.02.128

Reference yield:

: 852158-07-7
toluene-4-sulfonic acid 5-ethyl-6-methyl-3-nitro-2-oxo-1,2-dihydro-pyridin-4-yl ester

: 852158-15-7
methanesulfonic acid 3-amino-5-ethyl-4-(2-formyl-phenylsulfanyl)-6-methyl-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: LiCl / tetrahydrofuran / Heating

2: 95 percent / DIPEA / CH₂Cl₂ / 0.03 h / 20 °C

3: 78 percent / K₂CO₃ / CH₂Cl₂ / 10 h / 20 °C

4: 95 percent / H₂ / Pd/C / ethanol / 0.5 h / 760 Torr

5: 234 mg / TBAF / tetrahydrofuran; acetic acid / 12 h / 20 °C

6: Dess-Martin periodinane / CH₂Cl₂ / 0.08 h

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 6: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2005.02.128