phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

Base Information

Chemical Name:phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester
CAS No.:1606161-71-0
Molecular Formula:C₄₈H₅₀NO₉P
Molecular Weight:815.9
Hs Code.:

Synonyms:phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

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Chemical Property of phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

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Technology Process of phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

There total 6 articles about phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1606161-70-9
N-benzyloxy-N-((2S,3S,4R)-2,3,4-tris-benzyloxy-5-hydroxypentyl)formamide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1606161-71-0
phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

Guidance literature:: N-benzyloxy-N-((2S,3S,4R)-2,3,4-tris-benzyloxy-5-hydroxypentyl)formamide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at -78 ℃;

With triethylamine; In dichloromethane; acetonitrile; at -78 - 20 ℃;

Reference yield:

: 1606161-69-6
N-benzyloxy-N-((2S,3S,4R)-2,3,4-tris-benzyloxy-5-triisopropylsilanyloxy-pentyl)-formamide

: 1606161-71-0
phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2.1: 1H-tetrazole / dichloromethane; acetonitrile / 20 °C

2.2: -78 °C

2.3: -78 - 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 108713-89-9
(2R,3R,4R)-2,3,4-tris-benzyloxy-5,5-bis-ethylsulfanyl-pentan-1-ol

: 1606161-71-0
phosphoric acid dibenzyl ester (2R,3S,4S)-2,3,4-tris-benzyloxy-5-(benzyloxy-formyl-amino)pentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; dmap / 14 h / 20 °C

2.1: N-Bromosuccinimide / water; acetone / 0.5 h / 0 °C

3.1: pyridine / methanol / 24 h / 60 °C

3.2: 0.33 h

4.1: Carbonyldiimidazole / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6.1: 1H-tetrazole / dichloromethane; acetonitrile / 0.67 h / 20 °C

6.2: 0.33 h / -78 °C

6.3: -78 - 20 °C

With pyridine; 1H-tetrazole; dmap; N-Bromosuccinimide; Carbonyldiimidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile;