N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester
CAS No.:914800-93-4
Molecular Formula:C₂₄H₂₈N₂O₉S
Molecular Weight:521.549
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

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Chemical Property of N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

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Technology Process of N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

There total 4 articles about N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 914800-92-3
N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-serine

: 100867-23-0
4-sulfamoylbenzoic acid benzyl ether

: 914800-93-4
N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 ℃; for 10h;
DOI:10.1080/07328300600778785

Reference yield:

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 914800-93-4
N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 1-hydroxybenzotriazole; N,N'-diisopropylcarbodiimide / dimethylformamide / 12 h / 20 °C

2: 72 percent / ethyldiisopropylamine; PyBOP / CH₂Cl₂ / 10 h / -20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328300600778785

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 914800-93-4
N-(tert-butoxycarbonyl)-O-[1-13C]acetyl-L-seryl-4-sulfamoylbenzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0.5 h / 20 °C

1.2: 784 mg / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

2.1: 72 percent / ethyldiisopropylamine; PyBOP / CH₂Cl₂ / 10 h / -20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1080/07328300600778785