[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester
CAS No.:1282529-47-8
Molecular Formula:C₂₄H₂₂BrN₅O₃S
Molecular Weight:540.44
Hs Code.:

Synonyms:[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

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Chemical Property of [5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

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Technology Process of [5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

There total 7 articles about [5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1189815-93-7
8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

: isopropyl hydrazine hydrochloride salt

: 25508-19-4
N-benzyloxycarbonyl-S-methyl-isothiourea

: 1282529-47-8
[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

Guidance literature:: 8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid; N-benzyloxycarbonyl-S-methyl-isothiourea; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 24h;

isopropyl hydrazine hydrochloride salt; With sodium hypochlorite; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In N,N-dimethyl-formamide; at 95 ℃; for 2h;

Reference yield:

: 141106-23-2
8-bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one

: 1282529-47-8
[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / diethyl ether / 2 h / 0 - 20 °C

2.1: ethanol / 96 h / Reflux

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 24 h / 20 °C

4.2: 2 h / 95 °C

With water; bromine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol;

Reference yield:

: 170638-88-7
4-(3-bromophenoxy)butanoic acid

: 1282529-47-8
[5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid (PPA) / toluene / 5 h / 110 °C / Celite

2.1: bromine / diethyl ether / 2 h / 0 - 20 °C

3.1: ethanol / 96 h / Reflux

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 24 h / 20 °C

5.2: 2 h / 95 °C

With water; bromine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; toluene;