(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

Base Information

Chemical Name:(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone
CAS No.:221119-08-0
Molecular Formula:C₃₂H₄₁N₅O₆
Molecular Weight:591.707
Hs Code.:

(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

Synonyms:(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

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Chemical Property of (5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

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Technology Process of (5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

There total 4 articles about (5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026169-88-9
(R)-3-[(S)-2-((S)-2-{[(S)-1-((S)-2-Amino-butyryl)-pyrrolidine-2-carbonyl]-amino}-butyrylamino)-3-benzyloxy-propionylamino]-3-phenyl-propionic acid

: 221119-08-0
(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 185212-61-7
N-(t-butoxycarbonyl)-(2S)-aminobutyryl-L-proline

: 221119-08-0
(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pentafluorophenyl diphenylphosphinate, DIEA / dimethylformamide

2: LiOH / tetrahydrofuran; H₂O

3: HCl*dioxane

4: HBTU, HOBt, DIEA / dimethylformamide / 15 h

With lithium hydroxide; pentafluorophenyl diphenyl-phosphinate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrochloric acid 1,4-dioxane; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)02423-X

Reference yield:

: 221119-05-7
(S)-1-((S)-2-tert-Butoxycarbonylamino-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

: 221119-08-0
(5S,9R,12S,15S,17aS)-12-Benzyloxymethyl-5,15-diethyl-9-phenyl-dodecahydro-3a,6,10,13,16-pentaaza-cyclopentacyclohexadecene-4,7,11,14,17-pentaone

Guidance literature:: Multi-step reaction with 5 steps

1: LiOH / tetrahydrofuran; H₂O

2: 80 percent / pentafluorophenyl diphenylphosphinate, DIEA / dimethylformamide

3: LiOH / tetrahydrofuran; H₂O

4: HCl*dioxane

5: HBTU, HOBt, DIEA / dimethylformamide / 15 h

With lithium hydroxide; pentafluorophenyl diphenyl-phosphinate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrochloric acid 1,4-dioxane; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)02423-X