(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

Base Information

Chemical Name:(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine
CAS No.:195985-79-6
Molecular Formula:C₂₁H₂₁N₃
Molecular Weight:315.418
Hs Code.:

Synonyms:(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

Chemical Property:

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Technology Process of (R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

There total 3 articles about (R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 195985-79-6
(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

Guidance literature:

Reference yield:

: 195985-78-5
(R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine-2,5-dione

: 195985-79-6
(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

Guidance literature:: With borane-THF; In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/jm000248z

Reference yield:

: 195984-32-8
(R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-2,5-dione

: 195985-79-6
(R)-2,3,4,5-Tetrahydro-3-(phenylmethyl)-7-(4-pyridinyl)-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4 / toluene / 16 h / 110 °C

2: BH₃*THF / tetrahydrofuran / 18 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; In tetrahydrofuran; toluene; 1: Arylation / 2: Reduction;
DOI:10.1021/jm000248z