4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate

Base Information

• Chemical Name: 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate
• CAS No.: 1449428-69-6
• Molecular Formula: C₂₈H₂₅Cl₂N₃O₆S₂
• Molecular Weight: 634.561

Synonyms:4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate

Chemical Property of 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate

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Technology Process of 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate

There total 6 articles about 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-amino-3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-6-yl)phenyl acetate (1449429-08-6) + 2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride → 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate (1449428-69-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

4-(4-acetoxyphenyl)cyclohexan-1-one → 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate (1449428-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; morpholine / ethanol / 2 h / Reflux

2: pyridine / dichloromethane / 20 °C

With morpholine; pyridine; sulfur; In ethanol; dichloromethane; 1: |Gewald Aminoheterocycles Synthesis;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

4-(4-hydroxyphenyl)cyclohexan-1-one (105640-07-1) → 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)phenyl acetate (1449428-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 18 h / 20 °C

2: sulfur; morpholine / ethanol / 2 h / Reflux

3: pyridine / dichloromethane / 20 °C

With morpholine; pyridine; sulfur; In pyridine; ethanol; dichloromethane; 2: |Gewald Aminoheterocycles Synthesis;

DOI:10.1016/j.ejmech.2013.05.013

upstream raw materials:

4-(2-amino-3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-6-yl)phenyl acetate

4-(4-hydroxyphenyl)cyclohexan-1-one

2,4 dichlorobenzoic acid

2,4-dichloro-5-(chlorosulfonyl)benzoic acid

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